郝伟 研究员

办公室：5号楼906

电话：010-82629302

电子信箱：weihao@iccas.ac.cn

ORCID: https://orcid.org/0000-0001-9493-6894

 

教育和工作经历：

2006–2010	江苏大学，学士学位
2011–2016	北京大学，博士学位(导师：席振峰教授、张文雄教授)
2016–2017	美国康奈尔大学，博士后（导师：林松教授）
2018–2021	美国Scripps研究所，博士后（导师：Prof. Donna G. Blackmond）
2021–2022	北京大学，研究助理（导师：张文雄教授）
2022-至今	中国科学院化学研究所，研究员

荣誉与奖项：

2022	Organic Division Horizon Prize: Robert Robinson Award in Synthetic Organic Chemistry，英国皇家化学会（集体奖）
2021	Green Chemistry Challenge Award，美国环保署（集体奖）
2016	优秀博士论文，北京大学
2015	国家奖学金
2014	陶氏化学可持续发展创新二等奖
2014	北京大学光华奖学金
2014	北京大学三好学生
2010	江苏大学优秀毕业生

研究方向：

1. 基于反应动力学研究反应机理
2. 机理导向的不对称催化新方法发展

 

 

代表性论文：

1. Hao, W.; Joe, C.; Darù, A.; Ayers, S.; Ramirez, A. Sandhu, B.; Daley, R. A.; Chen, J. S.; Schmidt, M. A.; Blackmond, D. G.Kinetic and Thermodynamic Considerations in the Rh-Catalyzed Enantioselective Hydrogenation of 2-Pyridyl Substituted Alkenes. ACS Catal. 2022, 12, 5961-5969.
2. Hao, W.; Joe, C.; Ayers, S.; Darù, A.; Daley, R. A.; Domanski, M.; Chen, J. S.; Schmidt, M. A.; Blackmond, D. G. Ru-Catalyzed Enantioselective Hydrogenation of 2-Pyridyl Substituted Alkenes and Substrate-Mediated H/D Exchange. ACS Catal. 2022, 12, 1150-1160.
3. Hao, W.; Bay, K. L.; Harris, C. F.; King, D. S.; Guzei, I. A.; Aristov, M.; Zhuang, Z.; Plata, R. E.; Hill, D. E.; Houk, K. N.; Berry, J. F.; Yu, J.-Q.; Blackmond, D. G. Probing Catalyst Speciation in Pd-MPAAM-Catalyzed Enantioselective C(sp³)-H Arylation: Catalyst Improvement via Destabilization of Off-Cycle Species. ACS Catal. 2021,11, 11040-11048.
4. Hao, W.; Harenberg, J. H.; Wu, X.; MacMillan, N. S.; Lin, S. Diastereo- and Enantioselective Formal [3+2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed Radical Redox Relay. J. Am. Chem. Soc. 2018, 140, 3514-3517.
5. Hao, W.; Wu, X.; Sun, J. Z.; Siu, J. C.; MacMillan, S. N.; Lin, S. Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N‑Acylaziridines and Alkenes. J. Am. Chem. Soc. 2017, 139, 12141-12144.
6. Hao, W.; Wei, J.; Geng, W.; Zhang, W.-X.; Xi, Z.Transfer of Aryl Halide to Alkyl Halide: Reductive Elimination of Alkylhalide from Alkylpalladium Halide Containing syn-b-Hydrogens. Angew. Chem. Int. Ed.2014, 53, 14533-14537.
7. Hao, W.;^§ Wei, J.;^§ Chi, Y.; Walsh, P. J.; Xi, Z. A DFT Study on Conversion of Aryl Iodides to Alkyl Iodides: Reductive Elimination of R–I from Alkylpalladium Iodide Complexes with Assessable b-Hydrogens. (^§Equal contribution) Chem. Eur. J. 2016, 22, 3422-3429.
8. Hao, W.; Wang, H.; Ye, Q.; Zhang, W.-X.; Xi, Z. Cyclopentadiene-Phosphine/Palladium Catalyzed Synthesis of Indolizines from pyrrole and alkenyl or aryl dibromides. Org. Lett. 2015,17, 5674-5677.
9. Hao, W.; Wang, H.; Walsh, P. J.; Xi, Z.Combining Pd (π-allyl) Cp and PPh₃ as a Unique Catalyst for Efficient Synthesis of Alkyliodo Indoles via C (sp³)–I Reductive Elimination. Org. Chem. Front. 2015, 2, 1080-1084.
10. Hao, W.; Geng, W.; Zhang, W.-X.; Xi, Z.Palladium-Catalyzed One-Pot Three- or Four-Component Coupling of Aryl Iodides, Alkynes, and Amines through C-N Bond Cleavage: Efficient Synthesis of Indole Derivatives. Chem. Eur. J. 2014, 20, 2605-2612.
11. Gnaim, S.; Bauer, A.; Zhang, H.-J.; Chen, L.; Gannet, C.; Malapit, C. A.; Hill, D.; Vogt, D.; Tang, T.; Daley, R.; Hao, W.; Zeng, R.; Quertenmont, M.; Beck, W. D.; Kandahari, E.; Vantourout, J. C.; Echeverria, P.-G.; Abruna, H.; Blackmond, D. G.; Minteer, S.; Reisman, S.; Sigman, M. S.; Baran P. S. Cobalt-electrocatalytic HAT for Functionalization of Unsaturated C–C Bonds.Nature, 2022, 605,687-695.
12. Huang, Y.;^†Knouse, K. W.;^†Qiu, S.;^†Hao, W.;^‡Padial, N. M.;^‡Vantourout, J. C.;^‡Zheng, B.; Mercer, S. E.; Lopez, J. O.; Narayan, R.; Olson, R. E.; Blackmond, D. G.; Eastgate, M. D.; Schmidt, M. A.; McDonald, I. M.; Baran, P. S. A P(V)-Platform for Oligonucleotide Synthesis. Science 2021, 373,1265-1270. (^†These authors contributed equally to this work.^‡ These authors contributed equally to this work.)
13. Gao, Y.; Hill D. E.; Hao, W.; McNicholas, B. J.; Vantourout, J. C.; Hadt, R. G.; Reisman, S. E.; Blackmond, D. G.; Baran, P. S. Electrochemical Nozaki–Hiyama–Kishi Coupling: Scope, Applications, and Mechanism. J. Am. Chem. Soc. 2021,143, 9478-9488.
14. Chen, Y.-Q.; Singh, S.; Wu, Y.; Wang, Z.; Hao, W.; Verma, P.; Qiao, J. X.; Sunoj, R. B.; Yu, J. Q. Pd-Catalyzed γ‑C(sp³)−H Fluorination of Free Amines. J. Am. Chem. Soc. 2020, 142, 9966-9974.
15. Wu, X.; Hao, W.; Ye, K.-Y.; Jiang, B.; Pombar, G.; Song, Z.; Lin, S. Ti-Catalyzed Radical Alkylation of Secondary and Tertiary Alkyl Chlorides Using Michael Acceptors. J. Am. Chem. Soc. 2018, 140, 14836-14843.
16. Yang, Q.; Liu, L.; Chi, Y.; Hao, W.; Zhang, W.-X.; Xi, Z. Rhodium-Catalyzed Intramolecular Carbosilylation of Alkynes via C(sp³)–Si Bond Cleavage. Org. Chem. Front.2018, 5, 860-863.
17. Yin, J.; Ye, Q.; Hao, W.; Du, S.; Gu, Y.; Zhang, W.-X.; Xi, Z. Formation of Cyclopenta[c]pyridine Derivatives from 2,5-Disubstituted Pyrroles and 1,4-Dibromo-1,3-butadienes via Pyrrole-Ring One-Carbon Expansion. Org. Lett.2017, 19, 138-141.
18. Ouyang, K., Hao, W.; Zhang, W.-X.; Xi, Z. Transition-Metal-Catalyzed Cleavage of C–N Single Bonds. Chem. Rev. 2015, 115, 12045-12090.
19. Geng, W.; Wang, C.; Guang, J.; Hao, W., Zhang, W.-X.; Xi, Z. 1,2,3,4-Tetrasubstituted Cyclopentadienes and Their Applications for Metallocenes: Efficient Synthesis through Zirconocene- and CuCl-Mediated Intermolecular Coupling of Two Alkynes and One Diiodomethane. Chem. Eur. J. 2013, 19, 8657-8664.
    1. Geng, W.; Zhang, W.-X.; Hao, W.; Xi, Z. Cyclopentadiene−Phosphine/Palladium-Catalyzed Cleavage of C−N Bonds in Secondary Amines: Synthesis of Pyrrole and Indole Derivatives from Secondary Amines and Alkenyl or Aryl Dibromides. J. Am. Chem. Soc. 2012,134, 20230-20233.