手性超分子催化剂 手性超分子催化剂

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手性超分子催化剂      

       利用超分子识别与组装的基本原理,发展新型超分子手性催化剂及实现催化反应的超分子选择性调控是不对称催化领域新的研究热点和前沿。冠醚是一类具有柔性骨架结构的富电子大环阳离子主体分子,对于碱金属离子、碱土金属离子、有机铵离子及一些缺电子中性分子等都能够进行选择性识别,在超分子化学中显示出独特的魅力。为此,我们开展了基于冠醚/金属冠醚结构的超分子手性金属催化剂研究,发展了新颖的准轮烷手性配体/催化剂以及手性金属冠醚催化剂,实现了主客体相互作用对催化性能的调控,为手性配体/催化剂的构筑提供了新途径。

Figure 1. Design of Supramolecular Chiral Ligands Based on Psuedorotaxanes

 

Figure 2. Design of Supramolecular Chiral Catalysts Based on Metallacrown Ethers

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8. Tianli Wang, Ya Chen, Guanghui Ouyang, Yan-Mei He,* ZhiyanLi and Qing-Hua Fan,* "Solvent-Regulated Asymmetric Hydrogenation of Quinoline Derivatives in Oligo(Ethylene Glycol)s through Host–Guest Interactions", Chem.Asian J. 2016, 11, 2773–2777.

7.Guang-Hui Ouyang, Yan-Mei He, Yong Li, Jun-Feng Xiang, Qing-Hua Fan*, "Cation-Triggered Switchable Asymmetric Catalysis with Chiral Aza-CrownPhos", Angew. Chem. Int. Ed. 201554, 4334-4337.    

6. Guang-Hui Ouyang, Yan-Mei He,* Qing-Hua Fan*, "Podand-Based Dimeric Chromium(III)–Salen Complex for Asymmetric Henry Reaction: Cooperative Catalysis Promoted by Complexation of Alkali Metal Ions", Chem. Eur. J. 201420, 16454-16457 (hot papaer). 

 

5. Feng-Tao Song, Guang-Hui Ouyang, Yong Li, Yan-Mei He*, Qing-Hua Fan*, "New metallacrown ether catalysts containing phosphine-phosphite polyether ligands for Rh-catalyzed asymmetric hydrogenation: enhancements in activity and enantioselectivity", Eur. J. Org. Chem.2014, 30, 6713-6719.

 

4. Lei Wu, Yan-Mei He and Qing-Hua Fan,* "Controlled Reversible Anchoring of ƞ6-Arene/TsDPEN Ruthenium(II) Complex onto Magnetic Nanoparticles: A New Strategy for Catalyst Separation and Recycling", Adv. Synth. Catal. 2011, 353, 2915-2919.

3. Yong Li, Baode Ma, Yanmei He, Feng Zhang and Qing-Hua Fan,* "Chiral Metallacrown Ethers for Asymmetric Hydrogenation: Alkali-Metal Ion Mediated Enhancement of Enantioselectivity", Chem. Asian J. 2010, 5, 2454-2458.

2. Yong Li,* Zhiling Wang, Yanmei He and Qinghua Fan, "Advance in Preparation and Application of Supramolecular Bidentate Phosphorus Ligands", Chinese J. Org. Chem. 2010, 30, 338-344.

1. Yong Li, Yu Feng, Yan-Mei He, Fei Chen, Jie Pan and Qing-Hua Fan,* "Supramolecular Chiral Phosphorous Ligands Based on A [2]Pseudorotaxane Complex for Asymmetric Hydrogenation", Tetrahedron Lett. 2008, 49, 2878-2881.