树状分子-DNA杂合体 树状分子-DNA杂合体

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树状分子-DNA杂合体

   两亲性DNA嵌段共聚物结合了两亲分子的微相分离特性和DNA的可编程、碱基配对等特性,作为一类新型的超分子构筑基元,在纳米材料和超分子领域显示出其它材料不可比拟的优势,已成为该研究领域的新增长点。为此,我们与清华大学刘冬生教授课题组合作,选择具有不同分子体积、拓扑结构及亲疏水性质的有机高分子(特别是树状大分子),以及设计具有不同碱基序列或特异组装性能的DNA分子,通过化学键或DNA的碱基配对构建了系列两亲性DNA-有机高分子嵌段共聚物,它们在水相中展示了一些独特的组装行为及组装形貌。

Figure. Design, Synthesis and Self-Assembly of DNA Block Copolymers

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12. Fen Wu, Juan Jin, Liying Wang, Pengfei Sun, Huanxiang Yuan, Zhongqiang Yang, Guosong Chen, Qing-Hua Fan*, Dongsheng Liu*, "Functionalization of DNA-Dendron Supramolecular Fibers and Application in Regulation of Escherichia coli Association", ACS Appl. Mater. Interfaces 20157, 7351−7356.  

11. Fen Wu, Yongshun Song, Zhiyong Zhao, Shusheng Zhang, Zhongqiang Yang, Zhibo Li, Ming Li*, Qing-Hua Fan*, Dongsheng Liu*, "Preparation and Self-Assembly of Supramolecular Coil−Rod−Coil Triblock Copolymer PPO−dsDNA−PPO", Macromolecules 201548, 7550−7556.

 

10. Fen Wu,Yiyang Zhang, Zhongqiang Yang*, "An Overview of Self-Assembly and Morphological Regulation of Amphiphilic DNA Organic Hybrids", Chin. J. Chem. 201533, 511-516.  

 

9. Zhiyong Zhao, Chun Chen, Yuanchen Dong, Zhongqiang Yang, Qing-Hua Fan*, Dongsheng Liu*, "Thermally Triggered Frame-Guided Assembly", Angew. Chem. Int. Ed. 2014, 5313468-13470.  

8. Zhiyong Zhao, Fen Wu, Zhongqiang Yang,* Dongsheng Liu and Qing-Hua Fan,* "Synthesis and Self-Assembly of DNA-Aliphatic Polyether Dendron Hybrids", Acta Chim. Sinica 2013, 71, 549-554.

 7. Zhiyong Zhao, Liying Wang, Yu Liu, Zhongqiang Yang, Yan-Mei He, Zhibo Li, Qing-Hua Fan* and Dongsheng Liu,* "Ph-Induced Morphology-Shifting of DNA-b-Poly(Propylene Oxide) Assemblies", Chem. Commun. 2012, 48, 9753-9755.

6. Liying Wang, Yu Feng, Zhongqiang Yang, Yan-Mei He, Qing-Hua Fan* and Dongsheng Liu,* "Reversibly Controlled Morphology Transformation of An Amphiphilic DNA–Dendron Hybrid", Chem. Commun. 2012, 48, 3715-3717.

 

 5. Jin-Liang Lv, Zhi-Yong Zhao, Zhong-Qiang Yang, Dong-Sheng Liu* and Qing-Hua Fan,* "Synthesis of Dendritic Oligodeoxyribonucleotide Analogs with NonionicDiisopropylsilyl Linkage", Tetrahedron 2011, 67, 9080-9086.

4. Liying Wang, Yu Feng, Yawei Sun, Zhibo Li, Zhongqiang Yang, Yan-Mei He, Qing-Hua Fan* and Dongsheng Liu,* "Amphiphilic DNA-Dendron Hybrid: A New Building Block for Functional Assemblies", Soft Matter 2011, 7, 7187-7190.

 

3. Yawei Sun, Huajie Liu, Lijin Xu,Liying Wang, Qing-Hua Fan* and Dongsheng Liu,* "DNA Molecular Motor Controlled Dendron Association", Langmuir 2010, 26, 12496-12499.

2. Ping Chen, Yawei Sun, Huajie Liu, Lijin Xu,* Qinghua Fan and Dongsheng Liu,* "A ph Responsive Dendron-DNA-Protein Hybrid Supramolecular", Soft Matter 2010, 6, 2143-2145.

1. Enjun Cheng, Yongzheng Xing, Ping Chen, Yang Yang, Yawei Sun, Dejian Zhou,* Lijin Xu, Qinghua Fan and Dongsheng Liu,* "A pH-Triggered, Fast-Responding DNA Hydrogel", Angew. Chem. Int. Ed. 2009, 48, 7660-7663.