王志坚 (Zhi-Jian Wang)

Postdoc Fellow

Lawrence Berkeley National Lab, Life Sciences Division (056-100) One Cyclotron Road, Berkeley, CA 94720, Mail stop 55R0121

Work: 510 486 6361; Cell: 510 323 6110

Email: zhijianwang@lbl.gov and wzjxtun@gmail.com

Education Background

2003. 9–2008. 7, Ph.D. in Organic Chemistry, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing, China. advisor Prof. Qin-Hua Fan

1999. 9-2003. 7, B.S. in chemistry, Xiangtan University, Xiangtan, China.

Research Interests

Radiotracer development

Drug discovery

Organic synthesis

 

Awards

2011, Medicinal Chemistry Travel Grant Award, Medicinal Chemistry Division, American Chemical Society, Anaheim, California, United States.

2007, Prize by the Chairman of Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.

2007, Tsingtao Oceanic Chemical Engineering Prize, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.

Representative Publications

1. Z. Wang, G. Deng, Y. Li, Y. He, W. Tang, Q. Fan, Enantioselective Hydrogenation of Quinolines Catalyzed by Ir (BINAP)- Cored Dendrimers: Dramatic Enhancement of Catalytic Activity, Org. Lett. 2007, 9, 1243-1246.

2. H. Zhou, Z. Li, Z. Wang, T. Wang, L. Xu, Y. He, Q. Fan, J. Pan, L. Gu, A. S. C. Chan, Hydrogenation of Quinolines Using a Recyclable Phosphine-Free Chiral Cationic Ruthenium Catalyst: Enhancement of Catalyst Stability and Selectivity in an Ionic Liquid, Angew. Chem. Int. Ed. 2008, 47, 8464-8467.

3. Z. Li, T. Wang, Y. He, Z. Wang, Q. Fan, J. Pan, L. Xu, Air-Stable and Phosphine-Free Iridium Catalysts for Highly Enantioselective Hydrogenation of Quinoline Derivatives, Org. Lett. 2008, 10, 5265-5268.

4. Z. Liu, Y. He, Z. Wang, Q. Fan, Synthesis, Optical Properties, and Spectral Stability of Chiral Dendronized Binaphthyl-Containing Polyfluorene Derivatives, J. Polym. Sci. Part A: Polym. Chem. 2008, 46, 886-896.

5. Z. Wang, H. Zhou, T. Wang, Y. He, Q. Fan, Highly Enantioselective Hydrogenation of Quinolines under Solvent-Free or Highly Concentrated Conditions, Green chem. 2009, 11, 767-769.

6. W. Yin, M. S. Kabir, Z. Wang, S. K. Rallapalli, J. Ma, J. M. Cook, Enantiospecific Total Synthesis of the Important Biogenetic Intermediates along the Ajmaline Pathway, (+)-Polyneuridine and (+)-Polyneuridine Aldehyde, as well as 16-Epivellosimine and Macusine A, J. Org. Chem. 2010, 75, 3339-3349.

7. B. D. Fischer, S. C. Licata, R. V. Edwankar, Z. Wang, S. Huang, X. He, J. Yu, H. Zhou, E. M. Johnson, J. M. Cook, R. Furtmüller, J. Ramerstorfer, W. Sieghart, B. L. Roth, S. Majumder, J. K. Rowlett, Anxiolytic-like Effects of 8-Acetylene Imidazobenzodiazepines in a Rhesus Monkey Conflict Procedure, Neuropharm. 2010, 59, 612-618.

8. A. Di Lio, D. Benke, M. Besson, J. Desmeules, Y. Daali, Z. Wang, R. Edwankar, J. M. Cook, H. U. Zeilhofer, HZ166, a Novel GABAA Receptor Subtype-selective Benzodiazepine Site Ligand, is Antihyperalgesic in Mouse Models of Inflammatory and Neuropathic Pain, Neuropharm. 2011, 60, 626-632.

9. O. A. Namjoshi, A. Grzybkowska, G. O. German, M. L. Van Linn, Z. Wang, J. R. Deschamps, J. M. Cook, Development of a Two-Step Route to 3-PBC and βCCt, Two Agents Active against Alcohol Self-Administration in Rodent and Primate Models, J. Org. Chem., 2011, 76, 4721–4727.

10. Q. Chen, P. D. Yim, N. Yuan, J. Johnson, J. M. Cook, S. Smith, C Ionescu-Zanetti, Z. Wang, L. A. Arnold, C. W. Emala. Comparison of cell expression formats for the characterization the GABAA channels using a microfluidic patch clamp system. ASSAY and Drug Development Technologies, 2012, 10, 325-335.

11. O. A. Namjoshi, Z. Wang, S. K. Rallapalli, E. M. Johnson, Y. Johnson, H. Ng, J. Ramerstorfer, Z. Varagic, W. Sieghart, S. Majumder, B. L. Roth, J. K. Rowlett, J. M. Cook, Search for α3β2/3γ2 Subtype Selective Ligands That are Stable on Human Liver Microsomes, Bioorg. Med. Chem., 2013, 21, 93-101.

 

Patents

1. GABAergic Receptor Subtype Selective Ligands and Their Uses, J. M. Cook, T. S. Clayton, H. D. Jain, S. K. Rallapalli, Y. T. Johnson, J. Yang, M. M. Poe, O. A. Namjoshi, Z. Wang, US20120295892 A1, published 11/22/2012.

2. Selective Agents for Pain Suppression, J. M. Cook, S. Huang, R. V. Edwankar, O. A. Namjoshi, Z. Wang, US20100317619, Published 12/16/2010.

3. Method for Asymmetric Catalytic Hydrogenation of Quinoline Derivatives, Q. Fan, Z. Li, H. Zhou, Y. He, L. Xu, Z. Wang, X. Chen, L. Gu, Chinese Patent: CN 101585808 A, Published 11/25/2009.